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This could be related to production of catecholamines by the

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Canada Goose Jackets One reason for this may be the fact that although resting supine sympathetic activity (and thus blood pressure) tends to be low after SCI, some studies do report an appropriate increase in peripheral resistance when upright in SCI individuals, despite presumed disruption of the sympathetic control.49 canada goose outlet, 50, 51 It is likely that some other mechanism is responsible for the increased peripheral resistance following orthostasis in SCI individuals. This could be related to production of catecholamines by the adrenal medulla,50 although recent evidence suggests that this is unlikely (see below), a large and rapid release of vasopressin upon postural change to levels sufficient to exert a pressor effect,52 spinal reflexes and veno arteriolar reflexes6 or peripheral adrenoceptor hyper responsiveness.34 Although circulating supine resting catecholamine levels, particularly noradrenaline, are low in high SCI, there is a coincident hyper responsiveness of adrenoceptors below the lesion site34 such that if there were to be any increase in noradrenaline levels (eg via activation of the renin system),6 the peripheral adrenoceptors would be likely to respond strongly. However, several investigations have shown that in SCI individuals, the levels of both adrenaline and noradrenaline are abnormally low while supine,6 and that SCI individuals fail to increase catecholamine levels in response to an orthostatic challenge (Claydon et al, unpublished observations; Figure 3). Canada Goose Jackets

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